Seratrodast
CAS No. : 112665-43-7
(Synonyms: AA 2414)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $43 | In-stock |
| 25mg | $76 | In-stock |
| 50mg | $107 | In-stock |
| 100mg | $150 | In-stock |
| 500mg | $430 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B0774 |
| M.Wt: | 354.44 |
| Formula: | C22H26O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity.
In Vitro:Pretreatment with Seratrodast (5 μM; 2 h) can inhibit ferroptosis induced by RSL3 (HY-100218A) or Erastin (HY-15763) in HT22 cells; and down-regulate the phosphorylation level of JNK[3]/ Pretreatment with s
Seratrodast (5, 10 μM; 2 h) can inhibit ROS generation and lipid peroxidation induced by 1 μM Erastin (HY-15763) in HT22 cell[3].
In Vivo:Seratrodast (3, 9, 20 mg/kg; po; pre-treated, once daily for 5 days) inhibits neuronal ferroptosis in the pentylenetetrazole-induced mouse epilepsy model, thereby reducing epileptic seizure[3].
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