A-804598
CAS No. : 1125758-85-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $30 | In-stock |
| 5mg | $60 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $530 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100483 |
| M.Wt: | 315.37 |
| Formula: | C19H17N5 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 32 mg/mL |
A-804598 is a CNS penetrant, competitive and selective P2X7 receptor antagonist with IC50s of 9 nM, 10 nM and 11 nM for mouse, rat and human P2X7 receptors, respectively[1]. IC50 & Target: IC50: 9 nM (mouse P2X7 receptor), 10 nM (rat P2X7 receptor), 11 nM (human P2X7 receptor)[1] In Vitro: Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity[2]. In Vivo: A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease[3].
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