Riparin


CAS No. : 112356-54-4

(Synonyms: Riparin III)

112356-54-4
Price and Availability of CAS No. : 112356-54-4
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Cat. No. : HY-121966
M.Wt: 287.31
Formula: C16H17NO4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 112356-54-4 :

Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca2+ influx and inhibiting the release of intracellular calcium ion stores[1]. In Vitro:In rat depolarized uterus, Riparin inhibits in a reversible and noncompetitive manner CaCl2-induced contraction, a response mediated through voltage-dependent Ca2+ channels. The pD2 value for Riparin is 4.98. Riparin is ineffective in suppressing noradrenaline-induced sustained contractions of rabbit aortic strips[1].
In the aorta, Riparin (IC50 of 10.1 μM) inhibits intracellular calcium-dependent transient contractions[1].
In guinea-pig alveolar leucocytes, Riparin (IC50 3.2 μM) inhibits intracellular Ca2+ accumulation induced by the calcium ionophore A23187[1].

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