WAY-262611
CAS No. : 1123231-07-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $73 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $236 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $592 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-11035 |
| M.Wt: | 318.42 |
| Formula: | C20H22N4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 42 mg/mL |
WAY-262611 is a Wnt/β-Catenin agonist that increases bone formation rate with an EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor[1]. IC50 & Target:EC50: 0.63 μM (β-Catenin)[1] In Vitro:WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility[1]. In Vivo:WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1[1].
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