Ecopipam
CAS No. : 112108-01-7
(Synonyms: SCH 39166)
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $225 | In-stock |
| 25mg | $450 | In-stock |
| 50mg | $720 | In-stock |
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| Cat. No. : | HY-14690 |
| M.Wt: | 313.82 |
| Formula: | C19H20ClNO |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ecopipam (SCH 39166) is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam can be used for the research of schizophrenia, cocaine addition, and obesity[1][3].
In Vitro: Ecopipam (2 μM) completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].
In Vivo: Ecopipam (0.003-0.3 mg/kg; a single s.c.) abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3].
Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats[4].
Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].
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