Quetiapine (hemifumarate)
CAS No. : 111974-72-2
| Size | Price | Stock |
|---|---|---|
| 500mg | $30 | In-stock |
| 1g | $40 | In-stock |
| 5g | $119 | In-stock |
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| Cat. No. : | HY-B0031 |
| M.Wt: | 441.54 |
| Formula: | C23H27N3O4S |
| Purity: | >98 % |
| Solubility: | H2O : 1.25 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].
IC50 & Target: 5-HT Receptor[1]
In Vitro: Quetiapine (<100?μM; 24?hours) has no significant effect on cell viabilities[2].
Quetiapine (10?μM) inhibits NO release, which increased by LPS (0.1-100 ng/mL) in concentration-dependent manner[2].
Quetiapine (10?μM) also inhibits TNF-α synthesis[2].
In Vivo: Quetiapine (10?mg/kg/day; ingested) can alleviate the recruitment and activation of microglia and promote myelin repair in Cuprizone (CPZ)-induced chronic mouse model of demyelination[1].
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