Dithiodipropionic acid
CAS No. : 1119-62-6
| Size | Price | Stock |
|---|---|---|
| 25g | $14 | In-stock |
| 100g | $30 | In-stock |
| 500g | $36 | In-stock |
| 1000g | $59 | In-stock |
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| Cat. No. : | HY-W014395 |
| M.Wt: | 210.26 |
| Formula: | C6H10O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].
In Vitro:CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1].
CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1].
CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1].
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