KY02111
CAS No. : 1118807-13-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $45 | In-stock |
| 10mg | $72 | In-stock |
| 25mg | $145 | In-stock |
| 50mg | $235 | In-stock |
| 100mg | $350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13815 |
| M.Wt: | 376.86 |
| Formula: | C18H17ClN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
KY02111 is a canonical WNT signaling (β-catenin) inhibitor which promotes differentiation of hPSCs to cardiomyocytes. KY02111 can be used for the research of human cardiomyocyte regeneration[1].
In Vitro: KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs[1].
KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4[1].
KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner[1].
KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin[1].
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