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BIM 23042


CAS No. : 111857-96-6

111857-96-6
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Cat. No. : HY-103277
M.Wt: 1192.45
Formula: C63H73N11O9S2
Purity: >98 %
Solubility: H2O
Introduction of 111857-96-6 :

BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. BIM 23042 has 100-fold lower affinity for gastrin-releasing peptide (GRP) receptor (BB2). BIM 23042 inhibits Neuromedin B (HY-P0241), ICI 216140 and DPDM-bombesin ethylamide-induced Ca2+ release[1][2][3]. In Vitro: BIM 23042 (5 μM) competitively inhibits Neuromedin B-induced [3H]arachidonate release in huNMBR cells with a Ki of 49 nM[1].
In Vivo: BIM 23042 (10 μg; IV; a single bolus) attenuates neurogenic swelling and thermal and mechanical sensitization[2].

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