UCPH-101
CAS No. : 1118460-77-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $275 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $880 | In-stock |
| 100mg | $1290 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-10914 |
| M.Wt: | 422.48 |
| Formula: | C27H22N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. IC50 & Target: IC50: 0.66 μM (EAAT1)[1] In Vitro: UCPH-101 and UCPH-102 inhibit EAAT1 anion currents in a concentration-dependent manner, with KD values of 0.34±0.03 μM (Hill=1.3±0.13, n≥9) for UCPH-101 and 0.17±0.02 μM (Hill=0.97±0.11, n≥7) for UCPH-102. A small but significant decrease in the total expression levels of both HA-EAAT1 and HA-GLAST is observed in cells preincubated with 100 μM UCPH-101 (p=0.048)[1].
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