AZ12799734
CAS No. : 1117684-36-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $115 | In-stock |
| 10mg | $183 | In-stock |
| 25mg | $366 | In-stock |
| 50mg | $586 | In-stock |
| 100mg | $790 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123900 |
| M.Wt: | 370.43 |
| Formula: | C18H18N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
AZ12799734 is a selective, orally active TGFBR1 kinase inhibitor with an IC50 of 47 nM. AZ12799734 is also a pan BMP and TGFβ inhibitor[1].
IC50 & Target: TGFBR1, BMP, TGFβ[1]
IC50: 47 nM (TGFBR1)[1]
Kd: 740nM (TGFBR1)[1]
In Vitro: AZ12799734 inhibits ligand activated SMAD3/4 transcription[1].
AZ12799734 (10 nM; 24 h) inhibits phosphorylation of both SMAD1 and SMAD2[1].
AZ12799734 (500 nM; 36 h) inhibits TGFβ-induced migration in HaCaT epithelial cells[1].
In Vivo: AZ12799734 (0-400 mg/kg/day; p.o.; 3-7 days) induces histopathologic heart valve lesions in rat[2].
AZ12799734 (50 mg/kg; p.o.; once) shows total and free pharmacokinetic (PK) levels in the nude mouse with time over in vitro IC50 of 0.01885 μM[1].
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