Remacemide (hydrochloride)
CAS No. : 111686-79-4
(Synonyms: FPL 12924AA)
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| Cat. No. : | HY-107695 |
| M.Wt: | 304.81 |
| Formula: | C17H21ClN2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2].
IC50 & Target: IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
In Vitro: Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].
In Vivo: Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].
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