IAXO-102
CAS No. : 1115270-63-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $110 | In-stock |
| 5mg | $320 | In-stock |
| 10mg | $510 | In-stock |
| 25mg | $937 | In-stock |
| 50mg | $1500 | In-stock |
| 100mg | $2400 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-125171 |
| M.Wt: | 585.94 |
| Formula: | C35H71NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic;warming;heat to 60°C);Ethanol : 50 mg/mL (ultrasonic) |
IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1].
IC50 & Target: TLR4[1]
In Vitro: IAXO-102 (1-10 µM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells[1].
IAXO-102 (10 µM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC[1].
In Vivo: IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice[1].
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