Ponatinib (hydrochloride)
CAS No. : 1114544-31-8
(Synonyms: AP24534 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $32 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $140 | In-stock |
| 100mg | $210 | In-stock |
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| Cat. No. : | HY-108766 |
| M.Wt: | 569.02 |
| Formula: | C29H28ClF3N6O |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively[1].
In Vitro:Ponatinib hydrochloride (0.11, 017 μM, 24-48 h) can reduce the viability, migration, and function of human endothelial cells[2].
In Vivo:Ponatinib hydrochloride (dissolved in 25 mM citrate buffer (pH 2.75), 200 μL in volume, oral) protects mice from lethal influenza infection by inhibiting cytokine storm[3].
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