HSR6071
CAS No. : 111374-21-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $860 | In-stock |
| 50mg | $1350 | In-stock |
| 100mg | $2200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-U00133 |
| M.Wt: | 260.26 |
| Formula: | C10H12N8O |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic;adjust pH to 12 with NaOH) |
HSR6071, a pyrazinecarboxamide derivative, is an orally active and potent antiallergic agent. HSR6071 potently inhibits the experimental asthma in rat models[1][2].
In Vivo: The experimental asthma caused by IgE antibody in rats is inhibited by HSR-6071 (0.01-0.1 mg/kg; i.v.) in a dose-dependent manner. The bronchoconstriction mediated by IgE or IgG antibody in guinea-pigs is also prevented by HSR-6071 (0.3, 1,3 mg/kg; i.v.). HSR-6071 inhibits cyclic AMP phosphodiesterase activity and produces relaxation of the guinea-pig isolated trachea[1].
HSR-6071 inhibits the IgE-mediated histamine release with an IC50 of 0.46 nM. HSR-6071 is effective not only by i.v. but also by p.o. administration on the IgE mediated PCA in rats. The most potent inhibition with HSR-6071 is observed when it is given p.o. 5 min before the antigen challenge, indicating the rapid absorption of HSR-6071 through the gastrointestinal tract[2].
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