3-Bromopyruvic acid
CAS No. : 1113-59-3
(Synonyms: Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP)
| Size | Price | Stock |
|---|---|---|
| 5g | $19 | In-stock |
| 10g | $30 | In-stock |
| 25g | $45 | In-stock |
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| Cat. No. : | HY-19992 |
| M.Wt: | 166.96 |
| Formula: | C3H3BrO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 250 mg/mL (ultrasonic) |
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities[1][2][3].
In Vitro: 3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells[2].
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress[2].
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels[2].
In Vivo: 3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice[2].
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