Guancydine

Guancydine (Guancidine) is an orally active antihypertensive agent and vasodilator. Guancydine antagonizes the pressor effects of Angiotensin and Norepinephrine (HY-13715). Guancydine induces vasodilation in renal, mesenteric and cranial vascular beds, reduces peripheral resistance, increases cardiac output and lowers arterial blood pressure. Guancydine increases renal and forearm blood flow, reduces renal and forearm vascular resistance, alters cardiac systolic time, and reverses myocardial hypertrophy in hypertensive rats. Guancydine is applicable for research related to hypertension^[1][2][3][4]. In Vivo:Guancydine exerts antihypertensive effects in animals^[1].
Guancydine (8-30 mg/kg; p.o.) induces hypotension in hypertensive dogs at oral doses of 8-15 mg/kg, and causes hypotension, tachycardia and increased cardiac output in all experimental dogs at an oral dose of 30 mg/kg^[2].