Leucettine L41
CAS No. : 1112978-84-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $230 | In-stock |
| 10mg | $430 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-117049 |
| M.Wt: | 307.30 |
| Formula: | C17H13N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C) |
Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and CDC-like kinases (CLKs). Leucettine L41 can also inhibit GSK-3 singnaling. Leucettine L41 can inhibit cell apoptosis and ROS production. Leucettine L41 can promote β-cell cell cycle progression, cell proliferation and increase insulin secretion. Leucettine L41 can be used for the researches of neurological disease and metabolic disease, such as Alzheimer’s disease (AD) and diabetes[1][2].
In Vitro:Leucettine L41 (0.01-100 μM) increases viability and proliferation in MIN6 cells[2].
Leucettine L41 (5 μM, 24 h) increases cells in G2/M phase in MIN6 cells[2].
Leucettine L41 (5 μM, 24 h) increases insulin and C-peptide production in MIN6 cells[2].
Leucettine L41 improves insulin secretion in isolated mouse islets[2].
In Vivo:Leucettine L41 (0.4-4 μg, i.c.v.) prevents memory deficits and neurotoxicity in Aβ25-35-treated mice[1].
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