NF110
CAS No. : 111150-22-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $404 | In-stock |
| 10mg | $646 | Get quote |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-108671 |
| M.Wt: | 1096.91 |
| Formula: | C41H28N6Na4O17S4 |
| Purity: | >98 % |
| Solubility: | H2O : 40 mg/mL (ultrasonic;warming) |
NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1].
IC50 & Target: Ki: 36 nM (P2X3 Receptor)
In Vitro: NF110 shows an activity in the human tumour cell line panel, with IC30 of 362.3 μM[2].
NF110 inhibits HMGA2-DNA interactions with an IC50 of 0.87 μM[3].
In Vivo: NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA[1].
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