MTBT
CAS No. : 1110905-26-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $800 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-118034 |
| M.Wt: | 289.37 |
| Formula: | C14H11NO2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
MTBT is an anticancer agent and p38 MAPK activator. MTBT can inhibit tumor cell proliferation, induce cell cycle arrest and apoptosis. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. The specific inhibitor of p38 MAPK, Adezmapimod (HY-10256), can abrogate the cell cycle arrest induced by MTBT[1].
In Vitro:MTBT (2 mg/mL) causes more than 50% viability loss in A549, HeLa, and HepG2 cells[1].
MTBT (4.3-17.2 μM; 24 h) can inhibit colony formation in A549, HeLa, and HepG2 cells[1].
MTBT (0-17.28 μM; 0-72 h) can induce cell cycle arrest and apoptosis in A549 cells, and induce phosphorylation of p38[1].
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