RU-301
CAS No. : 1110873-99-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $465 | In-stock |
| 25mg | $790 | In-stock |
| 50mg | $1080 | In-stock |
| 100mg | $1450 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-119039 |
| M.Wt: | 480.46 |
| Formula: | C21H19F3N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis[1][2].
In Vitro:RU-301 (10 μM; 30 min) inhibits native TAMs activation in H1299 cells[1].
RU-301 (10 μM; 24 h) inhibits migration of H1299 and MDA-MB-231 cells[1].
RU-301 (10 μM; 14 days) inhibits growth of H1299 clonogenic cells under Gas6[1].
In Vivo:RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model[1].
RU-301 (300 mg/kg; i.p.; 3 times a week for 4 weeks) reduces liver fibrosis in mice[2].
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