Ginkgolic acid C17:1
CAS No. : 111047-30-4
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| 10mg | $457 | In-stock |
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| Cat. No. : | HY-N2116 |
| M.Wt: | 374.56 |
| Formula: | C24H38O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus[1][2][3][4][5].
IC50 & Target:PTEN; Phosphatase[1]
In Vitro: Ginkgolic acid C17:1 (30-50 μM; 24 h) reduces the viability of U266 cells with an IC50 about 64 µM, but has no effect on PBMCs[1].
Ginkgolic acid C17:1 (30-50 μM; 1.5-24 h) inhibits the phosphorylation of STAT3, up-regulates the expression of PTEN and SHP-1, and induces apoptosis in multiple myeloma cells[1].
Ginkgolic acid C17:1 (10-500 μM; 25 h) inhibits SARS-CoV-2-S pseudovirus in hACE2/HEK293T cells with an IC50 of 79.43 μM and the maximum half cytotoxic concentration (CC50) of 130.8 μM[2].
Ginkgolic acid C17:1 (1-20 μg/mL; 24 h) significantly and dose-dependent inhibits the biofilm formation of enterohemorrhagic Escherichia coli (EHEC) and Staphylococcus aureus, but did not affect the growth of EHEC cells[3].
Ginkgolic acid C17:1 (0-30 μg/mL; 0-72 h) inhibits SMMC-7721 cells with an IC50 of 8.5 μg/mL, and induces apoptosis and inhibits cell migration[4].
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