Annonacin
CAS No. : 111035-65-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $290 | In-stock |
| 5mg | $725 | In-stock |
| 10mg | $1235 | In-stock |
| 25mg | $2785 | In-stock |
| 50mg | $4455 | In-stock |
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| Cat. No. : | HY-N2877 |
| M.Wt: | 596.88 |
| Formula: | C35H64O7 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways[1][2][3][4].
In Vitro:Annonacin (1-10 μg/mL; 0-72 h) induces the death of a variety of cancer cell lines, and blocks cancer cells in G1 phase [2].
Annonacin 10 μg/mL; 0-24 h) induces apoptosis of T24 cells and enhance the expression of pro-apoptosis-related genes [2].
In Vivo:Annonacin (0-9 mg/kg; Subcutaneous osmotic pump; 3 days) increases tau phosphorylation in R406W+/+ mice [3].
Annonacin (85 nM/100 μL; Topical application; Twice a week for 22 weeks) has anti-cancer effect in mouse model of skin tumor [4].
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