Ruthenium red
CAS No. : 11103-72-3
(Synonyms: Ammoniated ruthenium oxychloride)
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|---|---|---|
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| 500mg | $100 | In-stock |
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| Cat. No. : | HY-103311 |
| M.Wt: | 786.35 |
| Formula: | [(NH3)5RuORu(NH3)4ORu(NH3)5]Cl6 |
| Purity: | >98 % |
| Solubility: | H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (ICa) blocker[1][2].
IC50 & Target:ICa[2]
In Vitro: Ruthenium red staining of intracellular organelles and structures seemed to depend on the time of exposure to this agent, as well on the concentration used[2].
Ruthenium red efficiently blocks the L-type calcium current in a dose-dependent manner in in guinea-pig isolated ventricular heart cells, with EC50 of 0.8 μM[2].
Ruthenium red (10 μM) blocks the sarcoplasmic Ca2+ release channels or the mitochondrial Ca2+ uptake, and blocks 26.7 % of the sodium current, and slows its inactivation time-course in guinea-pig isolated ventricular heart cells[2].
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