(-)-Taxifolin

(-)-Taxifolin is the low-activity isomer of Taxifolin. Taxifolin is an orally effective collagenase inhibitor with an IC₅₀ of 193.3 μM. Taxifolin dose-dependently reduces the levels of Smad-2, α-SMA, CTGF, type I collagen, NF-κB and FN in renal tissues, while decreasing serum levels of IL-1β, TNF-α, MDA, Scr and BUN, increasing SOD levels and reversing 27 serum metabolic biomarkers. Taxifolin inhibits the growth of a variety of pathogenic bacteria. Taxifolin can be used in studies related to renal fibrosis^[1][2]. In Vitro:(-)-Taxifolin is the low-activity isomer of Taxifolin. Compared with the common (+)-Taxifolin (HY-N0136), (-)-Taxifolin shows lower or no obvious activity in some systems, which is mainly due to the difference in spatial configuration between the two isomers, leading to distinct interaction modes with target proteins.