Decanedioic acid
CAS No. : 111-20-6
(Synonyms: Sebacic acid)
| Size | Price | Stock |
|---|---|---|
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| 1000g | $53 | In-stock |
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| Cat. No. : | HY-W014787 |
| M.Wt: | 202.25 |
| Formula: | C10H18O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 1 mg/mL (ultrasonic;warming;heat to 80°C) |
Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency[1][2][3].
In Vitro:Dodecanedioic acid, sodium salt (50-1000 μM; 40 min) inhibits Citrate transport in rat primary hepatocytes in a dose-dependent manner, with an estimated IC50 value of 96 μM[2].
In Vivo:Dodecanedioic acid, sodium salt (100 mg/kg/day; 8 weeks (prevention study); 6 weeks (reversion study)) prevents and reverses metabolic-associated liver disease and obesity and ameliorates liver fibrosis in a rat model of diet-induced obesity[2].
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