PF-04620110
CAS No. : 1109276-89-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $131 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $432 | In-stock |
| 100mg | $630 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13009 |
| M.Wt: | 396.44 |
| Formula: | C21H24N4O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic) |
PF-04620110 is a potent, selective and orally bioavailable diglyceride acyltransferase-1 (DGAT-1) inhibitor with an IC50 of 19 nM[1].
IC50 & Target: IC50: 19 nM (DGAT-1)[1]
In Vitro: PF-04620110 is orally bioavailable, has passive permeability(1x10-6 cm/s)[1].
PF-04620110 inhibits DGAT-1 with an IC50 of 19 nM, and inhibits triglyceride synthesis with an IC50 of 8 nM in HT-29 cells[2].
PF-04620110 is a highly selective inhibitor of DGAT-1 with >100-fold selectivity against a panel of lipid processing enzymes (human DGAT-2, several human acyl-CoA: cholesterol acyltransferase-1, wax alcohol acyltransferase-1/-2 and monacylglycerol acyltransferase-2/-3, and mouse MGAT-1)[2].
In Vivo: PF-04620110 (0.1-10 mg/kg; p.o.) reduces plasma triglyceride levels at doses of ≥0.1 mg/kg following a lipid challenge in rat[2].
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