Zopolrestat
CAS No. : 110703-94-1
(Synonyms: CP73850)
| Size | Price | Stock |
|---|---|---|
| 1mg | $38 | In-stock |
| 5mg | $76 | In-stock |
| 10mg | $115 | In-stock |
| 25mg | $253 | In-stock |
| 50mg | $380 | In-stock |
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| Cat. No. : | HY-19687 |
| M.Wt: | 419.38 |
| Formula: | C19H12F3N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications[1]. In Vitro: Zopolrestat is a potent inhibitor of the reduction of both glyceraldehyde and glucose by the human and rat enzymes[1]. In Vivo: Zopolrestat (2.5 mg/kg-50 mg/kg; p.o.; once-a-day for 5 days) and left untreated for 7 days) prevents accumulation of sorbitol in the kidney cortex of diabetic rats and normalize elevated renal blood flow in galactosemic rats[1].
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