Psammaplin A
CAS No. : 110659-91-1
| Size | Price | Stock |
|---|---|---|
| 100μg | $75 | Get quote |
| 1mg | $195 | In-stock |
| 5 mg | Get quote | |
| 10 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-N2150 |
| M.Wt: | 664.39 |
| Formula: | C22H24Br2N4O6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.3 mg/mL (ultrasonic;warming) |
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis[1][2][3][4][5][6][7][8].
IC50 & Target:IC50: 0.9 nM (DAC1)[1]
In Vitro:Psammaplin A inhibits the viability of A549 (GI50: 7.5 μM), MCF7 (GI50: 1.27 μM), and WI38 (GI50: 3.44 μM) cells[1].
Psammaplin A (72 h) inhibits the viability of A549 (IC50: 1.18 μM) and HCT116 (IC50: 1.62 μM) cells[2].
Psammaplin A (0.5-5 μM) inhibits bFGF-induced angiogenesis in bovine aortic endothelial cells (BAEC) in a dose-dependent manner[3].
Psammaplin A (0-100 μg/mL, 1-4 h) inhibits the toxicity of INT-407 cells induced by V. vulnificus in a concentration- and time-dependent manner[4].
Psammaplin A (0-100 μg/mL, 0-13 h) inhibits the growth of V. vulnificus in a concentration-dependent manner[4].
Psammaplin A (0-40 μM, 12 h) inhibits the viability of the macrophage cell line RAW264.7 in a concentration-dependent manner[6].
Psammaplin A (0-500 μM, 2 h) inhibits SV40 DNA replication in HeLa cells in a concentration-dependent manner.
Psammaplin A (125-500 μM, 30 min) inhibits the catalytic activity of topoisomerase I[6].
Psammaplin A (125-500 μM, 15 min) inhibits the binding activity of RPA to single-stranded DNA[6].
Psammaplin A (1-40 μM, 30 min) inhibits the activity of polymerase α-primase in a concentration-dependent manner[6].
Psammaplin A (3-30 μM, 4-16 h) induces apoptosis in T47D and MCF-7 cells[8].
In Vivo:Psammaplin A (30 mg/kg, i.p., three times a week for 35 d) has antitumor activity in mice in the A549 xenograft model[2].
Psammaplin A (5-50 μg, i.p., once) improves the survival rate of mice in the V. vulnificus-infected model[4].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- Psammaplin A
- Cat. No.:
- HY-N2150
- Quantity:
Your information is safe with us.