Epimedin A
CAS No. : 110623-72-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $110 | In-stock |
| 20mg | $198 | In-stock |
| 50mg | $396 | In-stock |
| 100mg | $600 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-N0257 |
| M.Wt: | 838.80 |
| Formula: | C39H50O20 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases[1][2][3].
In Vitro:Epimedin A (0.1-0.4 μM; 5 days) inhibits RANKL/M-CSF-induced osteoclast differentiation and reduces the mRNA expression of osteoclast-related genes in RAW264.7 cells. The mechanism involves the inhibition of the TRAF6/PI3K/AKT/NF-κB pathway[1].
In Vivo:Epimedin A (5-20 mg/kg; oral administration; 90 days) has a therapeutic effect in a rat model of osteoporosis[1].
Epimedin A (5-20 mg/kg; oral administration; 11 days) exerts an anti-inflammatory effect in a mouse model of allergic contact dermatitis (CD)[2].
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