YIGSR
CAS No. : 110590-64-2
(Synonyms: Laminin Fragment 929-933)
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $115 | In-stock |
| 10mg | $185 | In-stock |
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| Cat. No. : | HY-P0132 |
| M.Wt: | 594.66 |
| Formula: | C26H42N8O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
YIGSR (Laminin Fragment 929-933) is a polypeptide that inhibits tumor growth and metastasis of leukemia cells. YIGSR specifically binds to the 67kDa laminin receptor and regulates the expression of eNOS in endothelial cells. YIGSR can be used in leukemia-related research[1][2].
In Vitro:YIGSR (150 μg/mL) reduces the adhesion of porcine aortic endothelial cells to laminin I to approximately 50%[1].
YIGSR (150 μg/mL; 6 h) induces the detachment of approximately 80% of porcine aortic endothelial cells coated with laminin I under shear stress[1].
YIGSR (35 μg/mL) completely abolishes the elevation of eNOS mRNA expression induced by 2-fold shear stress in primary porcine aortic endothelial cells seeded on laminin I-coated plates, with administration performed 3 days after cell seeding[1].
YIGSR (35 μg/mL) completely inhibits shear stress-induced increase in eNOS in porcine aortic endothelial cells coated with laminin I[1].
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