N6-(4-Hydroxybenzyl)adenosine

N6-(4-Hydroxybenzyl) adenosine (Para-topolin riboside) is an equilibrative nucleoside transporter 1 (ENT1) inhibitor and a selective agonist of adenosine A_2a receptor (A_2aR), and also exhibits activity against P2Y12 receptor. N6-(4-Hydroxybenzyl) adenosine reduces ethanol intake and preference, attenuates operant conditioning-induced ethanol place preference, decreases the value of ethanol-related rewards, and inhibits collagen-induced platelet aggregation. N6-(4-Hydroxybenzyl) adenosine can be used in studies related to alcohol use disorder^[1][2]. In Vitro:N6-(4-Hydroxybenzyl)adenosine potently inhibits collagen-induced aggregation of washed human platelets with an IC₅₀ of 6.77 μM^[2]. In Vivo:N6-(4-Hydroxybenzyl)adenosine (0.1 mg/kg; i.p.; single dose) dampens ethanol preference and consumption in high ethanol drinking male C57BL/6J mice without changing total liquid intake^[1].
N6-(4-Hydroxybenzyl)adenosine (0.1 mg/kg; i.p.; single dose) dampens operant conditioning-induced ethanol zone preference in food-restricted male C57BL/6J mice without altering locomotion^[1].
N6-(4-Hydroxybenzyl)adenosine (0.1 mg/kg; i.p.; single dose) reduces the value of ethanol-containing reward in food-restricted male C57BL/6J mice, eliminating reward devaluation-induced differences in nose-poking behavior^[1].
N6-(4-Hydroxybenzyl)adenosine (0.1 mg/kg; i.p.; single dose) decreases the value of ethanol-only reward in food-restricted male C57BL/6J mice, eliminating reward devaluation-induced differences in nose-poking behavior^[1].
N6-(4-Hydroxybenzyl)adenosine (0.03-0.3 mg/kg; i.p.; single dose) at doses up to 0.1 mg/kg does not alter locomotor activity in male C57BL/6J mice, while 0.3 mg/kg reduces locomotion^[1].