BYK204165
CAS No. : 1104546-89-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $320 | In-stock |
| 100mg | $470 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-108632 |
| M.Wt: | 252.27 |
| Formula: | C15H12N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BYK204165 is a potent and selective PARP1 inhibitor. BYK204165 inhibits cell-free recombinant human PARP-1 (hPARP-1) with a pIC50 of 7.35 (pKi=7.05), and murine PARP-2 (mPARP-2) with a pIC50 of 5.38, respectively. BYK204165 displays 100-fold selectivity for PARP-1[1].
IC50 & Target: pIC50: 7.35 (hPARP-1), 5.38 (mPARP-2)[1]
In Vitro: In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pKi value of 7.05[1].
BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC50 of 5.75)[1].
In Vivo: BYK204165 is not investigated in vivo because of its short half-time (t1/2) of 23 min measured at rat microsomes in vitro[1].
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