ML-7 (hydrochloride)
CAS No. : 110448-33-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $54 | In-stock |
| 10mg | $87 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $310 | In-stock |
| 100mg | $445 | In-stock |
| 200mg | $578 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-15417 |
| M.Wt: | 452.74 |
| Formula: | C15H18ClIN2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 43 mg/mL;H2O : 1.43 mg/mL (ultrasonic) |
ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK (IC50=300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. IC50 & Target:IC50: 300 nM (MLCK)[1] In Vitro: ML-7 hydrochloride inhibits rabbit portal vein α1-adrenoceptor NSCC with IC50 of 0.8 μM[1]. The myosin light chain kinase (MLCK) inhibitor ML-7 hydrochloride (3 μ M and 10 μM) also attenuates the Dexmedetomidine (DMT)-induced contraction (p<0.05 versus control)[2]. In Vivo: In sham operated animals Evans Blue extravasation is not different between ML-7 hydrochloride and vehicle group (sham+vehicle: 0.26±0.02 OD/g; sham+ML-7: 0.26±0.02 OD/g). After CCI inhibition of MLCK with ML-7 results in a significant lower amount of intracerebral Evans Blue compared to vehicle treated animals (CCI+vehicle: 0.42±0.04 OD/g; CCI+ML-7: 0.35±0.05 OD/g, p=0.048)[3].
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