Dolastatin 10
CAS No. : 110417-88-4
(Synonyms: DLS 10; NSC 376128)
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $865 | In-stock |
| 100mg | $1385 | In-stock |
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| Cat. No. : | HY-15580 |
| M.Wt: | 785.09 |
| Formula: | C42H68N6O6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization. IC50 & Target:Tubulin[1] In Vitro: Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10?5-10?6 μg/mL (10?2-10?3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].
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