SNT-207858
CAS No. : 1104080-42-3
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| Cat. No. : | HY-11030 |
| M.Wt: | 689.54 |
| Formula: | C32H45Cl4N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. IC50 & Target: IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1] In Vitro: SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1]. In Vivo: SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].
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