Temocaprilat
CAS No. : 110221-53-9
(Synonyms: Temocapril diacid; Temocaprilate; RS 5139)
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| Cat. No. : | HY-A0117 |
| M.Wt: | 448.56 |
| Formula: | C21H24N2O5S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Temocaprilat (Temocapril diacid) is an inhibitor of angiotensin-converting enzyme (ACE). Temocaprilat alleviates the inhibitory effect of high glucose on the proliferation of aortic endothelial cells. Temocaprilat has potential applications in hypertension and vascular inflammation[1][2][3][4].
In Vitro:Temocaprilat (1, 10, 100 and 1000 nM; 72 h) relieves high glucose (22.2 mM) mediated inhibition of human aortic endothelial cells (HAECs) proliferation with dose-dependent manner. Temocaprilat inhibits oxidative stress induced by high glucose in HAECs[1].
Temocaprilat (1 µM; 10 min) increases protein kinase C (PKC) activity in HAECs[1].
Temocaprilat (0.1 µM) inhibits IL-1β induced IL-6 expression by reducing the stability of IL-6 mRNA[4].
In Vivo:Temocaprilat (1 mg/kg/d; i.v.; 4 weeks) significantly reduces systolic blood pressure with time-dependent manner in spontaneously hypertensive (SHR) rats. Temocaprilat improves myocardial fibrosis and oxidative stress in Wistar-Kyoto (WKY) rats and SHR rats[3].
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