AZD3147
CAS No. : 1101810-02-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $270 | In-stock |
| 10mg | $430 | In-stock |
| 25mg | $740 | In-stock |
| 50mg | $990 | In-stock |
| 100mg | $1380 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12652 |
| M.Wt: | 517.66 |
| Formula: | C24H31N5O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1].
IC50 & Target: IC50: 1.5 nM (mTOR), 0.92 μM (PI3Kα), 5.5 μM (PI3Kβ), 9.4 μM (PI3Kδ), 6.3 μM (PI3Kγ)[1].
In Vitro: AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells[2].
AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively[3].
In Vivo: The pharmacokinetic parameters of AZD3147[1].
| Parameter | Mouse | Dog |
| CL (mL/min/kg) | 78 | 16 |
| Vss (L/kg) | 2.3 | 2.2 |
| t1/2(h) | 0.9 | 1.9 |
| F% | 61 | 73 |
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