m-PEG4-propargyl
CAS No. : 1101668-39-6
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| 5g | $291 | Get quote |
| 25g | $1075 | Get quote |
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| Cat. No. : | HY-113921 |
| M.Wt: | 246.30 |
| Formula: | C12H22O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
m-PEG4-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-propargyl is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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