Methyl-Hesperidin

Methyl-Hesperidin is a glycoside compound. Methyl-Hesperidin has hypotensive, coronary dilating, smooth muscle relaxing, capillary stabilizing, choleretic, and anti-ulcer activities. Methyl-Hesperidin act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity. Methyl-Hesperidin potentiates coronary dilating actions of adenine nucleotides and 3'-AMP, enhances depressant action on isolated atria, and prolongs adenosine- and ATP-induced heart block in guinea pigs^[1][2]. In Vitro:Methyl hesperidin binds to HIV-1 reverse transcriptase with a binding energy of -8.8 kcal/mol via multiple interaction types, indicating it has affinity for the enzyme and could act as a competitive substrate to inhibit HIV-1 reverse transcriptase activity^[1].
Methyl-Hesperidin (2×10^-5-1×10^-3 M) does not meaningfully inhibit calf intestine-derived adenosine deaminase activity, with inhibition percentages ranging from 0.2-2.6%^[2]. In Vivo:Methyl-Hesperidin (0.5 mg/kg/min; i.v.; continuous infusion; single administration) markedly potentiates the coronary dilating action of 3'-AMP in nembutalized, open-chest dogs^[2].
Methyl-Hesperidin (1.0-2.5 mg/kg; i.v.; single injection) dose-dependently prolongs the duration of adenosine- and ATP-induced heart block in guinea pigs, with no effect on acetylcholine-induced block^[2].