Tepotinib
CAS No. : 1100598-32-0
(Synonyms: EMD-1214063)
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $550 | In-stock |
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| Cat. No. : | HY-14721 |
| M.Wt: | 492.57 |
| Formula: | C29H28N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 11.11 mg/mL (ultrasonic;warming;heat to 60°C) |
Tepotinib (EMD-1214063) is an orally active and highly selective, reversible, ATP-competitive c-Met inhibitor with an IC50 of 3 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib inhibits c-Met phosphorylation and induces autophagy. Tepotinib has antitumor effects[1][2][3].
In Vitro:Tepotinib inhibits IRAK4, TrkA, Axl, IRAK1, Mer, and TrkA with IC50s of 615, 1017, 1566, 2037, 2272, and 5716 nM, respectively[1].
Tepotinib inhibits HGF-induced c-Met phosphorylation, with an average IC50 of 6 nM in A549 cells[1].
Tepotinib (0.01 nM-30 μM) inhibits tumor cell proliferation and migration in vitro[1].
In Vivo:Tepotinib induces tumor regression in xenograft models and inhibits in vivo c-Met phosphorylation[1].
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