Procaspase-3/6 activator 1
CAS No. : 1100353-03-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $230 | In-stock |
| 25mg | $480 | In-stock |
| 50mg | $770 | In-stock |
| 100mg | $1230 | In-stock |
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| Cat. No. : | HY-10131 |
| M.Wt: | 411.41 |
| Formula: | C24H17N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C) |
Procaspase-3/6 activator 1 (compound 1541) is a highly specific and robust activator of executioner procaspases-3 and -6, with EC50 values of 2.4 ± 0.2 and 2.8 ± 0.3 μM, respectively. Procaspase-3/6 activator 1 does not activate procaspases-1 or -7[1].
In Vitro: Procaspase-3 at 100 nM was incubated with Procaspase-3/6 activator 1 (compound 1541) (100 nM to 100 μM). After a 4-hour incubation at 37°C, the samples were assayed for caspase activity by addition of Ac-DEVD-AFC. Low concentrations of 1541 induce activity of procaspase-3 with an EC50 of 2.4 μM, and, at high concentrations, inhibit with an IC50 of 34.0 μM[1].
Procaspase-3/6 activator 1 (compound 1541) exerts a similar inhibitory effect on active caspase-3 (IC50 = 35 μM), as seen for procaspase-3[1].
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