Sulcatone

Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis^[1][2][3][4]. In Vitro:Sulcatone (0-40 µM; 2-24 h) exhibits repellent and insecticidal activities (LC₉₅: 17.2 µL/L) against Sitophilus zeamais adults ^[1].
Sulcatone (0.03-4.24 mM; 7-10 days) has MICs of 3.5, 3.8, and 3.9 mM for F. verticillioides, A. parasiticus, and A. flavus, respectively^[1].
Sulcatona (1-1000 µM) can upregulate the expression of A2A adenosine receptors, inhibit the expression of CYP1B1 enzyme (10 µM)^[2]. In Vivo:Sulcatona (12.5-50 mg/kg; intravenous injection) has antihypertensive activity in SHR rats^[2].
Sulcatone (10 μg; applied to filter paper strips; single dose) elicits an electrophysiological response and significantly attracts female Platypus mutatus beetles^[3].