Sorbic acid

Sorbic acid is an effective, safe, and non-toxic food preservative. It can effectively inhibit most molds, yeasts, and certain bacteria. Sorbic acid is orally active and can enhance the growth performance of economically important animals (Duroc × Landrace × Yorkshire piglets) by activating the insulin-like growth factor system (IGF), and it can also lead to lipid accumulation by disrupting lipid clearance pathways^[1][2][3][4]。 In Vitro:Sorbic acid (1.0 or 3 mM, 7 days, the pH of the cytoplasm and vacuole was measured between 0 and 400 minutes) inhibits the growth activity of Aspergillus niger by inducing intracellular acidification^[4]。
In Vivo:Sorbic acid (0.5-4 g/kg, orally, once daily for 42 days) can improve the growth performance of Duroc × Landrace × Yorkshire piglets by regulating IGF (Insulin-like Growth Factor) system gene expression and hormone secretion^[2].
Sorbic acid (1 g/kg, p.o., once daily for 4 weeks) disrupts lipid clearance pathways in C57BL/6 mice (including decreased de novo lipogenesis, fatty acid internalization, very low-density lipoprotein (VLDL) secretion, autophagy, and β-oxidation), leading to hepatic lipid accumulation^[3]。