Fumaric acid
CAS No. : 110-17-8
| Size | Price | Stock |
|---|---|---|
| 100g | $10 | In-stock |
| 500g | $32 | In-stock |
| 1000g | $53 | In-stock |
| > 2 kg | Get quote | |
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| Cat. No. : | HY-W015883 |
| M.Wt: | 116.07 |
| Formula: | C4H4O4 |
| Purity: | >98 % |
| Solubility: | H2O : 11.11 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic) |
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].
In Vitro:Fumaric acid (50 μM, 24 h) inhibits p38 MAPK-dependent NF-κB signaling pathway and decreases the expression of eotaxin-1 in TNF-α-stimulated fibroblasts[2].
In Vivo:Fumaric acid (10 mL/kg, intravenously injected) is used to treat gestational hypertension by down-regulating the expression of KCNMB1 and TET1[3].
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