NSAH


CAS No. : 1099592-35-4

1099592-35-4
Price and Availability of CAS No. : 1099592-35-4
Size Price Stock
5mg $80 In-stock
10mg $140 In-stock
25mg $252 In-stock
50mg $405 In-stock
100mg $648 In-stock
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Cat. No. : HY-114503
M.Wt: 306.32
Formula: C18H14N2O3
Purity: >98 %
Solubility: DMSO : 62.5 mg/mL (ultrasonic)
Introduction of 1099592-35-4 :

NSAH is a reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1]. In Vitro: NSAH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells[1].
NSAH (0-10 μM, 2, 6, 24, or 72 h) exhibits potent anti-tumor activity in 3 cancer cell lines[1].
NSAH blocks S-phase progression well to the extent and timing of the decreases in dATP and dGTP[1].

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