Pyrithioxin

Pyrithioxin (Pyritinol) is an orally active neurodynamic compound. Pyrithioxin can promote the metabolism of glucose and amino acids, increase carotid blood flow and improve cerebral blood flow. Pyrithioxin exhibits anti-inflammation, anti-tumor and neuroprotective effect. Pyrithioxin can be used for the researches of cancer, inflammation, immunology, metabolic and neurological disease such as cerebral infarct, epilepsy, fibrosarcomas and rheumatoid polyarthritis^{[1][2][3][4][5][6][7]}. In Vitro:Pyrithioxin (dihydrochloride) (0.5-3 μg/mL) increases D-arabitol production from Candida parapsilosis by regulating glucose-6-phosphate dehydrogenase^[5].
In Vivo:Pyrithioxin (20 mg/kg, i.g., five times a week) prolongs survival time and induces tumor remission in WISTAR rats with 3-MC-induced subcutaneous fibrosarcomas^[2].
Pyrithioxin (200 and 600 mg/kg diet, added to the feed for free consumption, 6 weeks) elevates acetylcholine levels and enhances memory behavior in rats^[4].
Pyrithioxin (50-200 mg/kg, p.o.) reduces flinching behavior in Streptozocin (HY-13753)-induced diabetic rats^[7].