Utibapril
CAS No. : 109683-61-6
(Synonyms: FPL 63547)
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| Cat. No. : | HY-101681 |
| M.Wt: | 449.56 |
| Formula: | C22H31N3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Utibapril is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activities. In Vivo: Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril[1]. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts[2].
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