Neocryptotanshinone
CAS No. : 109664-02-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $375 | In-stock |
| 10mg | $665 | In-stock |
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| Cat. No. : | HY-119720 |
| M.Wt: | 314.38 |
| Formula: | C19H22O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].
IC50 & Target: Target: NF-κB, iNOS[1]
In Vitro: Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways[1].
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells[1].
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages[1].
In Vivo: Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].
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