Pamidronate (disodium pentahydrate)
CAS No. : 109552-15-0
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| Cat. No. : | HY-B0730 |
| M.Wt: | 369.11 |
| Formula: | C3H19NNa2O12P2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL;H2O : 7.14 mg/mL (ultrasonic) |
Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
In Vitro:Pamidronate disodium pentahydrate (0.001-1000 µM, 72 h) inhibits the cell viability of osteosarcoma cells POS, HMPOS and COS31, exhibits no cytotoxicity to fibroblasts[1].
In Vivo:Pamidronate disodium pentahydrate (3 mg/kg, ear vein injection, once monthly for 14 weeks) improves the bone structure, alleviates the degenerative changes of cartilage, exhibits protective effect against osteoarthritis in rabbit models[3].
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